Other names: 2-Fluoro-ara-A Monophosphate,
2-Fluoro-ara AMP, FAMP
Distributor: Schering SA
Fludarabine is available by prescription only
Fludarabine is given
through a vein (IV injection)
Indications: Fludarabine is used in the treatment
of the following medical conditions:
lymphocytic leukemia (CLL), in
patients for whom other forms of treatment have not worked
- Indolent or low-grade non-Hodgkin's lymphomas in
patients that have been unsuccessfully treated with other forms of treatment.
Fludarabine may also be prescribed for
other medical conditions not mentioned in this article; talk to your doctor or pharmacist for more information.
Dosage: to determine an effective dosage to
cancer, your doctor will consider
your general health, whether you are taking other chemotherapy drugs or not, the severity of the tumor and your
body mass index. Basing on these criteria, you health care provider will recommend the dosage most capable of
fighting the tumor. It is important that you take the medication as indicated by your oncologist.
Fludarabine comes as a powder to be
added to a medical fluid and injected intravenously. Usually, the appropriate dose is taken once daily for five
consecutive days, every 28 days. The injection takes about 30 minutes to be over.
Fludarabine can damage organs in your
body. It is very important during the treatment that you drink plenty of water to help your body get rid of the
toxic effects of the drug. This helps prevent kidney problems and improve the curative effects of the drug.
Fludarabine overdose can be dangerous. Even at normal dose, Fludarabine can lead to a decrease in white blood cells
and platelets, which can cause serious infections; therefore, avoid anything that might weaken your immune system
and the risk of infection while taking Fludarabine.
In addition, Fludarabine can also damage your nervous system, and lead to seizures, restlessness, and even coma. In
some patients, Fludarabine can cause lung damage, and other unpredictable life threatening health problems. During
the treatment, respect all appointments you have with your doctor. If you think you have taken an overdose, contact
your doctor or the poison control center nearest you as soon as possible.
It is basically
difficult to miss a dose of Fludarabine if you are present for your appointment. Do not neglect your
appointment; one missed dose of Fludarabine
can affect the entire treatment. If for some reasons you cannot be present at the hospital for the treatment,
contact your health care provider. Do not stay home because you are experience side effects; Fludarabine
cause adverse effects in most patients.
Fludarabine is contraindicated in the following conditions :
to Fludarabine or any of its constituents
with live attenuated vaccine
is not recommended or should be used with caution in patients whose general condition is poor, mainly those
- Opportunistic infections.
Mechanism of action (MOA): Fludarabine is the antimetabolite; it
cells by inhibiting their growth and preventing them from multiplying.
efore beginning a Fludarabine treatment, tell your doctor about all medications you are taking, whether
prescription or non prescription. Talk to your doctor before taking vitamins and nutritional supplements. Contact
your doctor before using the following medications:
Fludarabine tends to cause adverse effects in most patients; the most common Fludarabine side effects include:
- rash or
If the side
effects above persist for weeks, contact your oncologist. In addition, see your doctor if you experience any of
- chest pain
pain or discomfort
- fast or
- yellowing of the skin
of the arms, hands, feet, ankles, or lower legs
pain or tingling in the hands, arms, feet, or legs.