Brand name: Femara®
Manufacturer / Distributor:
Letrozole is available
by prescription only
Letrozole comes as a
pill to be taken by mouth
Indication: Letrozole is used to treat
hormone-dependent breast cancer in postmenopausal women. Letrozole is also used in the treatment of advanced
breast cancer in post-menopausal women who were treated unsuccessfully with anti-estrogen therapy.
medication can be taken with no problem right after a surgical therapy,
therapy and/or chemotherapy.
Letrozole can also be prescribed for other medical conditions not mentioned in this article; talk to your doctor or
pharmacist for more information.
Dosage: to determine an effective dosage to
cancer, your doctor will consider
your health, other chemotherapy drugs you are taking, the severity of the tumor and your body mass index (weight
/ size). Basing on these criteria, your physician will give effective doses of Letrozole capable of combating
the cancer. It is important to adhere to dosage recommended by your
doctor; do not change or stop taking the medication if you experience side effects.
Usually, Letrozole is recommended at a dose of 2.5 mg per day. You can take the drug with or without food, but
taking Letrozole after a meal reduces the risk of nausea or vomiting. It is important to take the medication around
the same time every day. Depending on your condition, your doctor may recommend you taking Letrozole for years.
Even if you feel better, it is necessary that you continue taking the drug. If for valid reasons you cannot
continue the therapy, talk to your doctor before taking any decision.
Storage: store Letrozole at room temperature
(15-25 ° C), away from heat above 40 ° C, light and moisture. Keep the medication out of the reach of children.
Letrozole and all other medications should not be used beyond the expiration date printed on the container.
Overdose: as with any drug, Letrozole overdose
may be dangerous, mainly if taken for long term. An overdose of Letrozole can damage the bone marrow, and lead
to a life threatening decrease in white blood cells and/or in platelets. If you take an overdose, contact your
doctor or the poison control center nearest you to reduce or prevent complications.
always take Letrozole
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missing, it can be dangerous. Contact your doctor or wait to go back to
your regular schedule. This applies not only to Letrozole but also any other drug.
is contraindicated in the following conditions:
to Letrozole or any of its ingredients
women or women who may become pregnant
who are breastfeeding.
Mechanism of action (MOA): Letrozole is classed as an aromatase
inhibitor, a group of chemotherapy drugs commonly used in the treatment of cancer. It reduces the production of
estrogens by blocking aromatase, an enzyme involved in their biosynthesis. The cells of breast cancer are
hormone-dependent; they need estrogens to multiply. The reduction of estrogen production can thus limit the
proliferation of cancer cells and prevents the tumor from growing or developing.
before starting a treatment with Letrozole, tell your doctor about all medications you are taking, whether
prescription or non prescription. Talk to your doctor before taking vitamins, nutritional supplements or any herbal
medications such as hormone replacement therapy and hormonal contraceptives (birth control pills, patches, rings,
and injections), tamoxifen (Nolvadex), and raloxifene (Evista) can
affect the therapeutic property of Letrozole, or increase the risk of developing side effects; contact your doctor
before using them.
Letrozole cause adverse effects in most patients; common Letrozole side effects include:
- loss of
- rash or
- pain or
redness, warmth in the face and neck
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
- chest pain
- Persistent cough.
santecheznous.com, Quels sont les effets secondaires possibles de ce médicament ?
- nlm.nih.gov, Side
effects : Letrexole